Two MBTA Green Line trolleys collided and derailed near the Government Center station Wednesday night, sending multiple people to the hospital and disrupting transit service downtown, officials said.

Three Green Line operators were taken to Massachusetts General Hospital with injuries, MBTA spokesman Joe Pesaturo said in an email Wednesday night. No passengers were treated for injuries, he said.

Jon Latino, a spokesman for the Boston Public Health Commission, said EMS took four people to the hospital.

The collision occurred shortly after 9:20 p.m. when a two-car, westbound train carrying between 20 and 25 passengers struck a two-car train that had no passengers and “was preparing to enter service at Government Center Station,” Pesaturo said. Both trains derailed, he said.

At the scene, MBTA Transit Police officers blocked people from going into the Government Center station and redirected people to the nearby Blue Line station.

Service was immediately suspended between Park Street and Union Square, the Massachusetts Bay Transportation Authority tweeted shortly before 10 p.m. Shuttle buses were to replace service to Lechmere station.

Green Line Update: Service is suspended between Park Street and Union Square due to a collision involving two Green Line trains near Government Center. Please use the Orange Line for alternate downtown service.

Green Line Update: Shuttle buses replace service between Lechmere and North Station due to an earlier accident near Government Center. Passengers can use the Orange Line to connect to the Blue Line at State and the Red Line at Downtown Crossing. https://t.co/u1TJ9qsBNR

The agency told riders to use the Orange Line for downtown service. Green Line service between Lechmere and North Station is being replaced with shuttle buses due to the accident, the MBTA said on Twitter.

Blue Line trains were bypassing Government Center in both directions “until further notice” because of the Green Line crash, the MBTA said on Twitter.

Blue Line Update: Trains will bypass Government Center until further notice. Please use Bowdoin or State Street for alternate service.

The crash is under investigation by the MBTA, Pesaturo said.

No further information was available late Wednesday night.

The collision is the latest incident to occur on an MBTA train and result in injuries, and it comes as the agency is under a rare federal review probing the safety of the nation’s oldest subway system.In a radio interview last month, Governor Charlie Baker said the federal safety inspection is “a good thing” that would bring national expertise to T policies.

Last summer, a Green Line train crashed into the one in front of it and injured 27 people. The driver, who had a history of speed infractions, has pleaded not guilty to negligence charges.

In April, a man was killed when his arm became trapped between the closed doors of a Red Line train at the Broadway MBTA station and he was dragged.

Globe correspondent Madison Mercado contributed to this report.

Nick Stoico can be reached at nick.stoico@globe.com. Follow him on Twitter @NickStoico.

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